Objective:<\/b>\u00a0To introduce the effect of a single course of betamethasone for pregnant women at risk of preterm delivery (PTD).<\/p>\n
Materials and methods:<\/b>\u00a0In this study, a single course of 12\u2009mg Bethamethasone was administered twice in 24\u2009h (between 24\u201334 gestational weeks) for antenatal corticosteroid prophylaxis. Four hundred ninety-three neonates fulfilled the inclusion criteria and they were categorized (259 singletons, 192 twins and 42 triplets who met the inclusion criteria) into two groups according to the utilization of antenatal corticosteroid as control (n<\/i>\u2009=\u2009202) and study (n<\/i>\u2009=\u2009291) groups. We used respiratory distress syndrome (RDS), congenital pneumonia, intraventricular hemorrhage (IVH), neonatal sepsis, and bronchopulmonary dysplasia (BPD) as primary outcomes for the evaluation of neonatal morbidity.<\/p>\n
Results:<\/b>\u00a0Study and control groups were similar in terms of clinical characteristics. RDS, congenital pneumonia, neonatal sepsis, and BPD rates were significantly higher in the study group (betamethasone) (p<\/i>\u2009=\u2009.05,\u00a0p<\/i>\u2009=\u2009.007, 0.003, and 0.004, respectively) between 24\u201334 gestational weeks (when the neonates of multiple pregnancies were excluded from the analysis, we have demonstrated that congenital pneumonia (p<\/i>\u2009=\u2009.033) and neonatal sepsis (p<\/i>\u2009=\u2009.030) were still significantly higher in the betamethasone group). The neonates of 24\u201328 gestational weeks were compared separately and we demonstrated that RDS (p<\/i>\u2009=\u2009.012), congenital pneumonia (p<\/i>\u2009=\u2009.022), IVH (p<\/i>\u2009=\u2009.044), neonatal sepsis (p<\/i>\u2009=\u2009.023), and BPD (0.001) were also more frequent in the study group. When the 28\u201332 gestational week data were compared, IVH (p<\/i>\u2009=\u2009.020) and neonatal sepsis (p<\/i>\u2009=\u2009.017) were more frequent in the single course betamethasone users. However, we could not demonstrate a significant difference between the control and study groups between 32\u201334 gestational weeks in terms of the primary neonatal outcomes used in this study.<\/p>\n
Conclusion:<\/b>\u00a0Single course antenatal betamethasone administration may be ineffective on the respiratory complications of preterm and very preterm infants while it may be unfavorable for extremely preterm infants.<\/p>\n","protected":false},"excerpt":{"rendered":"
Objective:\u00a0To introduce the effect of a single course of betamethasone for pregnant women at risk of preterm delivery (PTD). Materials and methods:\u00a0In this study, a single course of 12\u2009mg Bethamethasone was administered twice in 24\u2009h (between 24\u201334 gestational weeks) for antenatal corticosteroid prophylaxis. Four hundred ninety-three neonates fulfilled the inclusion criteria and they were categorized […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","msr-author-ordering":null,"msr_publishername":"","msr_publisher_other":"","msr_booktitle":"","msr_chapter":"","msr_edition":"","msr_editors":"","msr_how_published":"","msr_isbn":"","msr_issue":"X","msr_journal":"The Journal of Maternal-Fetal & Neonatal 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