{"id":343016,"date":"2016-12-29T10:23:26","date_gmt":"2016-12-29T18:23:26","guid":{"rendered":"https:\/\/cm-edgetun.pages.dev\/en-us\/research\/?post_type=msr-research-item&#038;p=343016"},"modified":"2018-10-16T22:22:08","modified_gmt":"2018-10-17T05:22:08","slug":"strong-association-human-leukocyte-antigen-associated-pol-gag-mutations-clinical-parameters-hiv-1-subtype-ae-infection","status":"publish","type":"msr-research-item","link":"https:\/\/cm-edgetun.pages.dev\/en-us\/research\/publication\/strong-association-human-leukocyte-antigen-associated-pol-gag-mutations-clinical-parameters-hiv-1-subtype-ae-infection\/","title":{"rendered":"A strong association of human leukocyte antigen-associated Pol and Gag mutations with clinical parameters in HIV-1 subtype A\/E infection."},"content":{"rendered":"<div id=\"abstractPlainText\">\n<div id=\"highlighting-container-plain\">\n<div id=\"abstract_text_plain\">Identification of human leukocyte antigen-associated HIV-1 polymorphisms (HLA-APs) in different global populations furthers our understanding of HIV-1 pathogenesis and may help identify candidate immunogens for HIV vaccines targeted to these populations. Although numerous population-based studies identifying HLA-APs have been conducted in HIV-1 subtype B- and subtype C-infected cohorts, few have focused on subtype A\/E.We investigated HLA-APs in a cohort of chronically HIV-1 subtype A\/E-infected Vietnamese individuals.HLA-APs in HIV-1 Gag, Pol, and Nef regions from 388 treatment-naive individuals chronically infected with HIV-1 subtype A\/E were analyzed using phylogenetically informed approaches.A total of 303 HLA-APs were identified. HLA-APs occurring at six positions in Gag and six positions in Pol were significantly associated with higher plasma viral load (pVL), whereas HLA-APs occurring at two positions in Gag and 13 positions in Pol were significantly associated with lower CD4 T-cell counts. Furthermore, the proportion of Pol codons harboring an HLA-AP specific to the host&#8217;s HLA correlated positively with HIV-1 pVL (R\u200a=\u200a0.22; P\u200a&lt;\u200a0.0001) and inversely with CD4 T-cell counts (R\u200a=\u200a-0.32; P\u200a&lt;\u200a0.0001). Similarly, the proportion of HLA-associated Gag codons harboring host-specific HLA-AP correlated inversely with CD4 T-cell counts (R\u200a=\u200a-0.13; P\u200a=\u200a0.01).These significant associations between HIV-1 amino acids adapted to Vietnamese HLA alleles and higher pVL and lower CD4 T-cell counts suggests that accumulation of cytotoxic T cells escape mutations may influence clinical outcomes in HIV-1 subtype A\/E-infected Vietnamese individuals.<\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div id=\"id4\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Identification of human leukocyte antigen-associated HIV-1 polymorphisms (HLA-APs) in different global populations furthers our understanding of HIV-1 pathogenesis and may help identify candidate immunogens for HIV vaccines targeted to these populations. Although numerous population-based studies identifying HLA-APs have been conducted in HIV-1 subtype B- and subtype C-infected cohorts, few have focused on subtype A\/E.We investigated 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