illustration of DNA strand and abstract shapes on a computer screen on a green gradient background

Medical, health, and genomics

Digital pathology helps decode tumor microenvironments for precision immunotherapy. GigaPath is a novel vision transformer that can scale to gigapixel whole-slide images by adapting dilated attention for digital pathology. In joint work with Providence and UW, we’re sharing Prov-GigaPath, the first whole-slide pathology foundation model pretrained on large-scale real-world data, for advancing clinical research and discovery.

GigaPath: Whole-Slide Foundation Model for Digital Pathology

Research Forum Ep2 | Panel | Transforming the Natural Sciences with AI

Research Forum 2 | Panel Discussion: Transforming the Natural Sciences with AI

white icons of first aid kit, DNA strand, laptop monitor with overlapping eye, and microscope on a blue and green gradient background

Scaling early detection of esophageal cancer with AI

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Microsoft Health Futures

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Microsoft Research Blog

ViSNet: A general molecular geometry modeling framework for predicting molecular properties and simulating molecular dynamics

February 29, 2024 | Tong Wang, Bin Shao, Tie-Yan Liu

Molecular geometry modeling is a powerful tool for understanding the intricate relationships between molecular structure and biological activity – a field known as structure-activity relationships (SAR). The main premise of SAR is that the biological…

The general model architecture of ViSNet. (a) Model sketch of ViSNet. ViSNet embeds the 3D structures of molecules and extracts the geometric information through a series of ViSNet blocks and outputs the molecule properties such as energy, forces, and HOMO-LUMO gap through an output block. (b) Flowchart of one ViSNet Block. One ViSNet block consists of two modules: i) Scalar2Vec, responsible for attaching scalar embeddings to vectors.; ii) Vec2Scalar. The inputs of Scalar2Vec are the node embedding, edge embedding, direction unit and the relative positions between two atoms.

Microsoft Research Blog

Research Focus: Week of February 19, 2024

February 21, 2024 | Anna Pavlenko, Joyce Cahoon, Yiwen Zhu, Brian Kroth, Jesús Camacho Rodríguez, Karla Saur, Sudipta Sinha, Stephen Schneider, Serena Hillman

In this issue: CaaSPER: vertical autoscaling algorithm dynamically maintains optimal CPU utilization; Improved scene landmark detection for camera localization runs faster, uses less storage; ESUS simplifies usability questionnaires for technical products and services.

Research Focus Week of February 19, 2024

Publication

Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data

Chibuikem Nwizu, Madeline Hughes, Michelle L. Ramseier, Andrew W. Navia, Alex K. Shalek, Nicolo Fusi, Srivatsan Raghavan, Peter S. Winter, Ava P. Amini, Lorin Crawford

bioRxiv | February 2024

Project

Publication

Self-Supervised Learning for Improved Optical Coherence Tomography Detection of Macular Telangiectasia Type 2

Shahrzad Gholami, Lea Scheppke, Meghana Kshirsagar, Yue Wu, Rahul Dodhia, Roberto Bonelli, Irene Leung, Ferenc B. Sallo, Alyson Muldrew, Catherine Jamison, Tunde Peto, Juan M. Lavista Ferres, Bill Weeks, Martin Friedlander, Aaron Y. Lee

JAMA Ophthalmology | February 2024

Project

Publication

Optimizing genomics pipeline execution with integer linear programming

Olesya Melnichenko, Venkat S. Malladi

February 2024

Publication

The GA4GH Task Execution Application Programming Interface: Enabling Easy Multicloud Task Execution

Alexander Kanitz, Matthew H. McLoughlin, Liam Beckman, Venkat S. Malladi, Kyle Ellrott

Computing in Science & Engineering | February 2024, Vol 26: pp. 30-39

Publication

CataractBot: An LLM-Powered Expert-in-the-Loop Chatbot for Cataract Patients

Pragnya Ramjee, Bhuvan Sachdeva, Satvik Golechha, Shreyas Kulkarni, Geeta Fulari, Dr. Kaushik Murali, Mohit Jain

February 2024

Project Project

Publication

Protein structure generation via folding diffusion

Kevin E. Wu, Kevin Kaichuang Yang, Rianne van den Berg, Sarah Alamdari, James Zou, Alex Lu, Ava P. Amini

Nature Communications | February 2024, Vol 15

Publication

Characterizing the Signal-to-noise Ratio and Spatio-temporal Resolution of an Imaging Transformer Model for CMR

Hui Xue

Journal of Cardiovascular Magnetic Resonance | February 2024, Vol 26

Publication

An Interactive Agent Foundation Model

Zane Durante, Bidipta Sarkar, Ran Gong, Rohan Taori, Yusuke Noda, Paul Tang, Ehsan Adeli, Shrinidhi Kowshika Lakshmikanth, Kevin Schulman, Arnold Milstein, Demetri Terzopoulos, Ade Famoti, Noboru Kuno, Ashley J. Llorens, Hoi Vo, Katsushi Ikeuchi, Fei-Fei Li, Jianfeng Gao, Naoki Wake, Qiuyuan Huang

February 2024

Project

Medical, health, and genomics

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