Age-related remodeling of the intestinal mucus barrier in pigs: implications for post-weaning diarrhea
- Cassiano Becker ,
- J. Elzinga ,
- M. K. Morsing ,
- C. Jørgensen ,
- M. Fredholm ,
- Michael Hansen ,
- S. S. Nielsen ,
- Jens Nielsen ,
- H. E. Jensen
Veterinary and Animal Science | , Vol 34
Highlights • Postnatal maturation drives major changes in goblet cells and mucus characteristics.• MUC2 and X409 show distinct age- and segment-dependent developmental patterns.• Disease-associated differences were predominantly identified in the jejunum.• Diarrheic pigs had fewer luminal goblet cells and reduced X409 labeling at day 67.• Timely mucus barrier maturation may be important for resilience post weaning.